He married Ann Clarke Biscoe in Baltimore County, Maryland, 9 Jul 1833.(39) Ann was born 8 Dec 1814. Ann was the daughter of Richard
Biscoe and Eleanor Clarke. Ann died 26 Nov 1864 at 49 years of age.
John Waters Boothe and Ann Clarke Biscoe had the following children:
16
i.
Anne E.3 Boothe(40) was born 2 Oct 1835. Anne died 3 Oct 1835 at less than one year of age.
17
ii.
Jane R. Boothe(41) was born 2 Oct 1835.
Jane died 3 Oct 1835 at less than one year of age.
18
iii.
Ellen Maria Boothe(42) was born 19 Dec
1836. Ellen died 16 Jul 1837 at less than one year of age.