6. Mary de Guise² de Lorraine (Claude of Guise³, Rene II⁴, Ferry II⁵) was born in Bar-le-Duc, France 22 Nov 1515.

She married twice. She married Louis II de Longueville Duc de Longeuville 4 Aug 1534. Louis was born 1510. She married James V Stuart 9 May 1538. James was born in Scotland 15 Apr 1512. James was the son of James IV Stuart and Margaret Tudor. James died 14 Dec 1542 in Fife, Scotland, at 30 years of age.

Mary de Guise de Lorraine and Louis II de Longueville Duc de Longeuville had the following children:

7 i. Francois III¹ de Longueville Duc de Longueville was born 1535. Francois died 1551 at 16 years of age.

8 ii. Louis de Longueville was born 1537.

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