22. Antoinette³ de Bourbon Duchess of Guise (Francois⁴, John II⁵ de Vendome) was born 25 Dec 1493. Antoinette died 22 Jan 1583 at 89 years of age.

She married Claude of Guise de Lorraine Duke of Guise 9 Jun 1513. Claude was born 20 Oct 1496. Claude was the son of Rene II de Lorraine Duke of Lorraine and Philippine von Geldern. Claude died 12 Apr 1550 at 53 years of age. (See Claude of Guise de Lorraine Duke of Guise for the children resulting from this marriage.)

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