1) After participating in the world's 1st Direct to Consumer Exome Genetic Pilot (I was 1 of 1000 in the whole world) it came to light that SOME Sinhalese people have a higher percent of mutations than seen before in other cultures.[This is what i was told by the head of bioinformatics at one of the Universities that analyzed]. That means some Sinhalese folks out there have illnesses that have not yet been diagnosed. You might be taking medicines that are for some symptoms, but it might not be the root cause and so the medicine might not be helping. I learned that 100 Sri Lankan Tamil people in England and 100+ Sri Lankan Tamils in Canada have been fully sequenced and studied re. health risks and genetic variations. This means they get better suited medicines, and medical diagnosis and answers.There have only been 2 Sinhalese people so far fully or Exome sequenced. We need the Genetic dep. at U of Colombo and other places to fully sequence and analyze more Sinhalese.In order for them to do that, i am sure they need funding.....private donors etc. I do not live in Sri Lanka so do not know fully.
One of the rare things that have come up is a gene mutation that affects liver. Geneticists do not yet know fully what that particular mutation involves. But part information they know:missing enzymes/proteins to process certain medicines, environmental toxins, some cleaning products, and even smoke/burning things. If you are abnormally sensitive to medicines or have had liver enlarging and doctors don't know why, or sensitivity to environmental things, Genova Diagnostics in the US has a wonderful test. It is the Dotoxigenomics tiny genetic test. So far, in me taking genetic tests, i have found Genova's test to be the most helpful. The Exome i participated in confirmed the results Genova had given me 5 years prior and no doctor paid attention.Now people are taking notice.
As i have done much genealogy for various related and unrelated families, i have noticed something. It is that many many Sinhalese families are having what looks somewhat like PCOS or other kinds of'womb problems' as one woman put it. Some have died from this. A facet of doing genealogy in North America is tabulating health things. This is why i asked even strangers (unrelated families) questions about health related things as i have done their genealogy for them.
I am writing these things because it would help alleviate severe suffering of some people. And i am wanting Sinhalese Sri Lankans to get more involved with genetics. It will bring answers to you and your family. And most of all, it would be lovely if people influence Sri Lankan Universities/genetic research places to do medical genetic research. That means them getting proper funding. Much of medicine is taylored to white people because they are the ones that have had money to influence pharmaceutical companies, University research projects etc. Chinese people have also been into this field the last few years because of Beiging Genomics doing cutting edge research on Chinese people. What about Sri Lankans? (as i mentioned Tamils are being studied, but what about other Sri Lankans and their health care?)
2) I have spearheaded a bit of a Samarasinghe/Samarasinha/Samarasinghe Sriwardena genetic study. A few families have participated. It has been fascinating to learn which families with Samarasinghe name are related, which are not. Am waiting for the Sriwardena rep to do the test and get results. So far a De Alwis Samarasinghe, 2 Perera Samarasinghe's, a Perera Samarasinha, and a Samarasinghe Sriwardena are involved in this study. Need more people with Samarasinghe/haname in their many names to participate. Esp. a Samarasinghe/ha Pieris/Peiris would be very beneficial.23andMe.com andGenebase.com are the 2 genetic companies that have been used.