Cynthia, I am researching the Miller family that was in Pickens Co in the 1800's, but have done some research on the Chalmers family as a result. Drury Miller, brother of my husband's 2great-grandfather Andrew Lewis Miller of Screven Ga, was living with the James Chalmers household in 1850 in Pickens Co. He was a business partner and possibly a relative of James Chalmers.
The Ferguson connection that I am aware of to the Chalmers family was that Mary Chalmers, daughter of James and his wife Eliza Campbell, married William A. Ferguson. William was the only son of Bryant Ferguson and Martha Cotton. Bryant had a brother named William who also lived in Pickens Co. Bryant and William were sons of Nathaniel Ferguson and Phoebe Carr of Kentucky.I don't know whether or not a George Ferguson was connected with this family.