Hi Patricia, I didn't find any of them in the U. S. Censuses. Do you have any additional info about them; where and when John and caroline were born?
You can also verify if John was a doctor in San Francisco by contacting the San Francisco Library. They will look in the yearly City/County Directories. You'll have to tell them which years. Go to sfpl.org/index.php?pg=2000001701 for contact info.