Henry, check with the local library for obit. The family resided most of their lives in Somerville, Middlesex Co, so try library there for obits. According to several documents for his children on familysearch.org, Joseph was b Liverpool Eng, and Isabel was bSt John NB Their dau Isabella was b 1896; d 1-9-1900 from pneumonia; bur Mt Hope Cem. Isabella Sr d 1920-30[nee KERR not KIER]
The b/dates on this marriage differ from 1900 census.1866 and 1871 respectively. 12-17-1888 Boston, Suffolk Co MA Joseph SHEPPHARD 26 s/o Joseph/Ann m. Isabella KERR 22  d/o Thomas/Elizabeth
dau Sarah Elizabeth b 6-29-1890; m.12-7-1915 George Melbourn KELLY, Somerville
Don't know what became of Edith 11-3-1896, Henry Arthur 4-14-1899, and Joseph 7-20-1901, altho Edith still at home 1920.Not able to locate family 1910 to see if boys still living. They also had son Joseph H Jr b/d 1893.
so we have..... Sarah Elizabeth Joseph Jr dau Isabella Edith F Henry Arthur Joseph Possible unnamed dau and Isabella are one in the same.