What info do you have that an Isaac was the husband of Margaret, and f/o James, Nancy, Mary, Isaac, Thomas? I'm not finding the family 1860 to confirm. It's interesting....the family is BRADLEY in 1870 Caldwell Co MO;1880 Ray Co MO, Margaret, James, Isaac, Thos are all listed as MARTIN [is this Isaac's middle name?].Either Margaret reverted to her maiden name, or she remarried.It's also possible she is not the m/o of all the children. Do you know who Nancy and Mary married?