Be wary of trees until you can confirm. I'm in-tune to everyone in your family from 1870 forward, but couldn't find anything prior, but think I've figured it out.Isaac and Thos are most likely BRADLEYs, but the others are MARTINs. 1850 Caldwell Co MO MARTIN Isaac 26 TN Margaret 20 TN William 4 MO Jane 2 MO John 2/12 MO
1860 Caldwell MARTIN Margaret 32 W F 13 [Wm] S J 12 [Jane] J ? 10 [John] J M 7 [James] N A 4 [Nancy Ann m. 12-31-1874 Enoch COX] M L 2 [Mary Louisa m. 3-18-1875 John Thomas MARTIN]
Isaac MARTIN d. 1858-60
One Margaret MARTIN m. Robert BRADLEY 7-21-1861 Caldwell, but not sure, but would fit your Isaac's birthdate.