My Peter Ryan was born 1849 in Culnakillew,near Lahardane,Co. Mayo, Ireland.His siblings were: John, Catherine, Bridget, Mary a half sister, Ellen Murray.
I don't know if there is a connection to your Ryans in Center which is pretty close to the same area in Nebraska as O'Neill.
I have no information on Peter's father, Patrick, but I suppose the possibility always exists that your Ryans could be cousins to mine via siblings of Patrick since the birthdates are close.Just don't have enough info.
Sorry.Wish I COULD find someone related to this family since my grandfather only had one son that lived.keep me in mind if you find any connection in the future and thanks for writing.