Linda, I don't know much about the Wise family. I corresponded witha Lynda Wise a few years back about them.
Paint Twp. 1850 Census
WISE Hugh, 60, carpenter, PA Polly, 58, VA Sally, 22, VA MArtha, 19, VA Paxton, 18, laborer, VA Franklin, 16, laborer, VA Wesley, 14, VA Nancy, 12, VA PAULEY, William, p, VA PERRY, John, 2, VA
The next household may be a brother: WISE Christopher,61, farmer, PA Catherine, 57, VA Catherine, 16, OH George, 13, OH Carey, (female) 11, OH
I have wondered if the John Perry listed with Hugh in 1850 was my gg-grandfather, John Perie. His surname was routinely misspelled as Perry on many documents. He was born in Tazewell Co. VA in 1847 to John and Mary Perie. According my grandmother's Bible he came to Ohio in 1850. That is about all I know of his origins.