In the 1850 census of Dayton, there is a household listed under Jacob Keefer as follows:
Jacob A. 26 MD O.C. 24 MD Samuel M. 22 MD Ephraim 17 MD Urilla 14 OH John L. 12 OH roll 713 2 ward Dayton, p164
I've found marriages for most of these folks in Montgomery Co, OH. Jacob Kiefer married Elizabeth Gano, 1853. I think O.C. is Charles C. who married Sarah Elizabeth Engle, 1850. Samuel Michael married Ann E. Marsh in 1858 and lived in Sacramento, CA. Ephraim D. married Martha E. Cridland in 1857. Urilla E. married John B. Kneisley in 1855.
There is a Fred Cressie Kiefer born 1868 in Ohio, that died in Los Angeles, CA. His mother's maiden name is listed as Gano, but I've not been able to find Jacob and Elizabeth in the Ohio census to confirm Fred's origins.
Can anyone shed light on any of the puzzle pieces?