I'll add the little extra I found to what Hugh and Alice gave you.It fleshes out the tree a little.When a young adult male disappears after the 1860 census, first thought is Civil War.No Jeffers or Jefferson Ramsey/Ramsay listed from AL on the Soldiers and Sailors site, but several "J." Ramseys, and a couple of "J." Ramsays.You might follow up on them.The following gives you a few more siblings of Isaac, maybe you can find descendants of one of them who knows a little more on the family.
1870 census Limestone Co, AL:
Terry, Eliza, 45, b SC - no land or personal listed Ramsay[sic], Mary 16, b AL - Farm Laborer " Lucy, 14, b AL - Farm Laborer " Jefferson, 12, b AL - Frm Lab " Isaac 10, b AL - Frm Lab " Mark, 8, b AL - At Home " Lilly 6, b AL - At Home " Rose 4, b AL - At Home Terry, John 12, b AL - Day Laborer " Joel, 10, b AL - Day Lab " Julia, 8, b AL - At Home " Malinda, 6, b AL - At Home
Who is Eliza????Two men named Terry on the 1860 Limestone Co, AL census, none with an Eliza.Did she lose a husband to the War, too?
You might check Limestone Co, AL land records.On 1860 census Jeffers owns land, what happened to it?