Thanks for the kind words. I'm very pleased when these posts are useful to others, since I have received so much help from other researchers myself over the years on these forums.
I'm sorry to be so late replying, but for weeks I have been submerged under the work I get paid for doing. I meant to write a long reply, but I won't have time for some weeks (I'm taking a new administrative job at the university I work in). So here is an interim reply.
Yes, there are relationships in your list, but most are that peculiar sort you find in genealogy--the individuals are related in their descendancy, but were not related as contemporaries. The present re-orders the past. An example: my 2ggf Emanuel Haney, who was captured during the Civil War while driving a herd of cattle from Kentucky to Tennessee to feed the Confederate troops, was part of a large troop of cavalry hastily assembled from remnants of other troops that included one Sterling Condry. They might have met, but if they had, they would have discovered no relation between them. Now they are distantly related, because descendants of my generation claim them both as ancestors. They are unrelated only if we imagine that the lines of relationship flow only forward in time. And all our genealogical efforts prove the opposite--our consciousness of ourselves flows backward, to include all those dead people in our sense of self.
So in that sense, the Mathews families are related to the Adcocks and Smiths, not because they married, but because the Adcock/Smith marriage produced a child who married a Hobson who married a Tillery, who in turn married a Mathews. So the contemporary Adcock/Smith families were related in their future to the Mathews with whom they were contemporaries.
And in that sense, the Allens, Laymans, and Runyans are related; an Allen/Rambo marriage produced Margaret Rambo who married Barefoot Runyan whose son married a Mullendore who came from a Layman line. The Wallen/Blevins line is related similarly to the Rice, Cox, and Justice lines through various of these combinations. If you imagine drawing out all these lines, humanity would look like a set of telephone cables attacked by a tornado. Sort of like my Christmas lights when I try to store them.
The one pair in your list with a different relationship is pretty grim. In Augusta Co, VA, one Christopher Millirons was suspected of having murdered John Mathews with his wife and children, by burning their house about them. Millirons, as the records show, owed money to Mathews. So far as I know from the court records, he was not formally charged, but only questioned.
I'm sure it is only a coincidence, since I know of no linguistic transformation that would make Wilburn and Lilburn variants of the same name, but the odd name in my mother's family is my 2ggf Lilburn Condry. No other man on either side bears that given name, and no wife is known to have that maiden name, and I have not lcoated the Condrys near any Lilburn family. But, as I say, I imagine this is only a phonetic accident.