I have some Agnello's in Detroit.I don't know if they're related to yours.
I have Giuseppe Agnello (b-abt. 1883) married to Giuseppa (Josephine)Bruno(b-abt 1885), who came over several times, the last time in 1921 with his wife and daughter, Antonia Agnello(b.abt. 1911).They were from Alcamo, Sicily, sailed in 1921 from Palermo on the ship "Asia" and moved to Detroit, Michigan.They had several other children (Older was Giuseppe, Jr.(b.-abt 1909)Younger was Angelina (Angie) and Gaspare (Spike). both born in Michigan.)
Antonia was my grandmother on my father's side.She married Michele Lazzara and had several children including my dad, all born in Detroit.
In 1921 they came over with Vita Agnello who appears to be related according to the ship log.They also traveled with Antonia Pirron of whom I know nothing about. (perhaps she was Josephine's mom?).It appears that the women used their maiden names even though they were married.
Giuesppe Sr. Died sometime before the 1950's.Giueseppe, Jr. did also.Gaspare died in the late 1960's.Antonia Died in the 1980's. Josephine died in 1963. Angie is still alive.
I'm not sure if this fits with the family you are researching.If it does, I have more information to share on the continuation of this tree.You can email me at email@example.com or you can post back and I will see it.