I was looking for my wife's gg grandmother, Lydia Alexander m. July 4, 1865 (Bastrop Co, Tx) Brinkley H. Tyler b 1837 Ms.My info was that her parents were John McCoy Alexander b. 1818 Wilson Co, Tn. and Drucilla McGee.
I found some names common to yours in 1880 Bastop Co, but they are listed as Farmer, not Doctors.
It's a long shot that they are yours but have similar names?
Note: that Jos Alexander named daughter Drennan and that John Alexander 75 Tn has wife whose name appears to be Hardinor (very hard to read)and a Henry Alexander 36 Tn is further down the same page.
Census 1880 Texas, Bastrop Co, Pct 6, Page 38, line 12 lists a Jos Alexander wm 28 merchant Tn/Tn/Tn, Mary wf 24 wife Tn/SC/Tn, and Drennan wf 1 daughter Tx/Tn/Tn. and Rachael Hemphill bf 60 servant Ky/Ky/Ky.
Census 1880 Texas, Bastrop Co, Pct 6, Page 38, line 16 lists a John Alexander wm 27 farmer Tn/Tn/Tn, Josephine wf 24 wife Tx/Tn/Al, Nettie wf 2 dau Tx/Tn/Tx.
Census 1880 Texas, Bastrop Co, Pct 6, Page 38, line 35 lists a Salom Alexander wf 35 Ark/Ark/Ark, John wm 8 son Tx/Tx/Ark, Anna wf 5 dau Tx/Tx/Ark.
Census 1880 Texas, Bastrop Co, Pct 6, Page 38, line 46 lists a Alfred Alexander wm 40 Tn/Tn/Tn, Mary wf 32 wife Tx/NC/SC, Thomas wm 12 son Tx/Tn/Tx, Emma wf 11 dau Tx/Tn/Tx, Anzi? wm 9 son Tx/Tn/Tx, Mary wf 7 dau Tx/Tn/Tx, Sidney wm 5 son Tx/Tn/Tx, Carrie wm 4 Tx/Tn/Tx, Ashbell wm 2 son Tx/Tn/Tx, Nora 4/12 Tx/Tn/Tx, Mark 67 wm father Tn/SC/SC, Emma 60 mother Tn/SC/SC.
Census 1880 Texas, Bastrop Co, Pct 6, Page 36, line 6 lists a John Alexander wm 75 Tn/SC/Sc, Hardi?? (Hardinor?) wf 61 wife n/SC/Sc, Mark wm 19 son Tx/Tn/Tx, Abbie wf 14 Tx/Tn/Tn.
Census 1880 Texas, Bastrop Co, Pct 6, Page 36, line 36 lists a Henry Alexander wm 32 Tn/Tn/Tn, Harriet 32 Tn/Tn/Tn, Teb??? wm 6 son Tx/Tn/Tn, Pearl wf 5 dau Tx/Tn/Tn, Butler wm 3 son Tx/Tn/Tn, Roy wm 1 son Tx/Tn/Tn