You said: "Sophronia Alexander m. William Johnson is my line. They settled in Brown Co., IN."
If Sophronia Alexander is your ancestor then neither Reuben Alexander in Albemarle County, Virginia nor Reuben Alexander who married Jane Smith in Madison County, Missouri in 1830 is related to your line.
Reuben, father of Sophronia, was b. in Pennsylvania, raised in North Carolina, spent a few years in Kentucky and then settled in Indiana where he died in 1822.
Or maybe you know that but I'm not clear from your posting . . . . if you want information on this family, I have lots of documented information.