The James E. Alford you mention is James Ellsworth Alford son of the Emery and Martha J. Alford you found.I am not certain but I do not believe they are related to George A. At present we don't know about the others you mention.
We are familiar with your George Andrew Alford who was the son of John and Ellen Alford.George and his wife Mary Ann are buried in Forest Lawn Cemetery in Kane, McKean Co., PA.
We would like to work with you on your Alfords and any Alfords of PA which you may "know."I'm with the Alford American Family Association, a non-profit corp; and we have interest in ALL Alfords (several spelling variations) from ALL periods and ALL places (especially in the US.)For more information check us out at www.alfordassociation.org.
We can keep this board posted but if possible I'd like to work with you via regular email where you can get me at GilAlford@Charter.net.