I don't know; however, my William GILREATH from Wilkes Co NC is in the Newberry Co SC area as well as CRENSHAWs, HERNDONs and RUTHERFORDs.
I know that Col. Benjamin CLEVELAND is on the Tugaloo--perhaps near the Cain Creek you mention?
At any rate, two of William GILREATHs son's are in Greenville by late 1700's to early 1800's.One son, Capt William GILREATH who served under CLEVELAND (with LENOIR) apparently stayed in Wilkes.
I have nothing yet to link my Charles ALLEN of Greenville with these men; however, I do think the Thomas ALLEN who dies in Greenville leaving minor children is probably his son Thomas and may be the same as the one mentioned with land on Paris' Ford of Saluda; and, possibly with a Pickens Co connection.
They do seem to move around (or own land in various areas).
Charles ALLEN and Isaac WICKLIFFE were apparently right down town on the Reedy River in Greenville; however,he is associated with people in the Milford area--north of the Enoree; and, also, had at least one son later mentioned with the Brushy Creek Bapt Chh.Some of the John WESTMORELAND children are at Clear Spring Bapt Chh; however, at least one daughter had married a PETTYPOOL and is in the Tigerville area--right near the Highway 11 Table Rock area and the road to Ashville NC.
Please keep me in mind if you find ALLEN connections to mine in the Greenville area.