Orange was formed in 1752 from Johnston, Bladen and Granville. Guilford was formed in in 1770 from parts of Orange and Rowan. However, Bute was formed in 1764 from Granville and Bute was abolished in 1779 to form the two new counties of Warren and Franklin. This is not geographically that same part of Granville that became Orange.
However, remember there is much movement of families which can be seen between the geographic area from Granville>Orange>Guilford and Rowan. The 'old trading path' route from Va thru Granville on to Rowan (Salisbury) seems to be responsible for a good bit of movement through this area. I think you'll find it is not unusual to find early deeds in these counties (I certainly have in Rowan) that reference one party being of Granville.
It may also be worth noting that in 1766, part of Northampton was annexed into Bute. Of course, this part of Bute became Warren in 1779 when Bute was abolished.