My great-great grandmother was Isabel Alvarez Betancourt. She was married to Ricardo(also called Natalio) Serrano who was said to be from Humacao. I haven't been able to find too much info on her or him but she apparently died by 1908. One certificate says she was from San Juan another says Bayamon. Other than that I have no other information. Her son with Ricardo was Francisco Serrano Alvarez(great-grandfather) supposedly born in Humacao.