I copied this from the Brewer List, and it might be a connection for you.The contributor is William W. Brewer, Jr., at firstname.lastname@example.org
Hi, I'm new to the list, so I thought I had better list my Brewers.The furthest back that I can go for sure is the marriage of my g-g-g-grandfather, Briant Brewer, who married Eliza Briggs on 16 Apr 1820 in Wayne County, Indiana.Later census records show that he was born in North Carolina in 1799 or 1798.He died sometime in 1845 in Fountain County, Indiana.There is strong reason to believe that he was the son of Thomas and Lucretia Brewer, who were married in Duplin County, North Carolina in 1792, but this is not proven.
Briant and Eliza moved to Fountain County and purchased land there in 1826 (their land entry was signed for Briant by James Briggs, a brother (?) of Eliza's?).Their children included Lorenzo Dow Brewer, Caroline Brewer, William Irwin Brewer, my g-g-grandfather Briant Brewer, Isaac Brewer, Minerva Brewer, and Eliza Brewer.
(More....but doesn't concern Isaac) Maybe William can help with some additional information.