I have encountered an 1860 MO census record with the following:
William Brewer 49 From Tennessee Mary A. 34 or 39From N. Carolina Isabel 22 John 19 Nancy 18 Sally 10 Fransie? 8 Thomas 13 Martha 6 Henry 4 Jasper & William (twins?) 2 children were born in Missouri, probably Randolph Co., Chariton/Jackson Township near Darksville/Huntsville MO
Reply to me if you think Mary was Cherokee or if you want clarification.