Thank you for the information about Elizabeth(Doup/Toop) Brinley. Since I posted my initial query I have found Elizabeth Brinley 67 yo b. PA in the 1850 Harrison County, Indiana census. She was living with John Brinley (36 yo b. IN) and his wife, Stacy, and several children.
Although John & Stacy were still in Harrison County in the 1860 census, I did not find Elizabeth. Presumably she died. But she could also have been living with other family somewhere else.
I will check wills and estate records just in case she left some property after her death. But perhaps someone has cemetery information for Harrison County that could help out.