The Louisa Wilson HOLMES who married Walter C BURKHISER in Pittsburgh PA is a relation.Her father was Thomas D HOLMES of Allegheny City/Northside, Allegheny Co, PA and her mother was Louisa Wilson PRYOR.
The marriage license for Walter & Louisa states that he was a clerk and living in Ingram PA; father John E BURKHISER and mother Armeda HIGH, both born in WV.They were married on Nov 29 1922 in Pittsburgh, Allegheny Co, PA by Frederick H WRIGHT, Minister.
I do have Louisa's obit: she died on Thursday, Feb 23 1978 in Pittsburgh / North Side; mother of Walter H of Toronto.There were three grandchildren and two great-grandchildren (no names given).
Louisa's father, Thomas D HOLMES, is my ggggf.This looks odd only in that I descend from Thomas' eldest child from his first marriage (born in 1856) and Louisa Wilson HOLMES was born abt 1902, the only child from his second marriage.
I know that Walter does not appear to be in the direct line that you are following, but if you have any further info on him, I'd love to see it to further my HOLMES notations.