Mariah Allen, b. abt 1800, married her older sister Nancy's husband Jeremiah Chandler after Nancy's death.When Nathaniel died, Mariah married Jeremiah Prater (Prather) 29 Dec 1835. Mariah and Jeremiah were my GGG Grandparents. It is certain that Mariah was a carrier of a disease called Gerstmann-Straussler-Scheinker-Disease. This is an inherited disease in which each child of an afflicted parent has a 50% chance of inheriting the genetic mutation which causes the disease. Do you have any information on the causes of death of descendants of Mariah Allen or any of her siblings? I have worked with the University of Illinois on the genealogy of Mariah and don't yet know if it was Mariah's mother or father who was also a carrier. The U of I has isolated the genetic mutation responsible for this extremely rare familial disease and it's a matter of great importance for the descendants to be located and informed of this potentiality and the ability to diagnose the disease either before or after the onset of symptoms. Symptoms are bad balance, mild dementia, walking problems, progressing to difficulty swallowing and lack of mobility.