The dominant tribes in the upstate of South Carolina during the late 1700's, early 1800's were the Cherokee and the Catawba. The Cherokee originally controlled land as far nort as Virginia and Kentucky and as far south as SC, Ga, Al. From NC, SC, and Va in the east to the Mississippi River. They lived in the northwestern part of SC. The Catawba controlled land east of there. There are records of the South Carolina govt sending militia to attack the Cherokee before and after the Revolution.
When the Federal Govt took the land from the Cherokee, the Cherokee wanted to free their slaves. The govt officials didnt want a lot of freedmen running around, so they forced the Cherokee to take their slaves with them.