Sue, I'm sure there is some kind of connection. I have an Anna E. Drake (d/o Nancy T. Busby and William Jackson Drake-all of Adair Co, KY) who was married to a Richard E. Colgin. Richard was born ca 1839, location unknown, and died 1922 in Freestone Co, Texas. Anna was born 1847 KY and died 1932 in Freestone Co, TX. Both are buried in Cotton Gin Cemetery in Freestone Co.
My KY Busby family had a couple of children who moved on to Carroll Co, MO while the rest moved on to TX, ca 1850. Some names associated by marriages are: DRAKE, THOMAS, WINFREY, GRAVES, SWEENEY, BANKS, TUCKER, HARDWICK, FAIR, and FITZPATRICK. All of these families were in KY and/or MO in the 1800's.