The Isaac Creek in Clay County, IL, is the son of Jefferson Creek.Jefferson Creek, born 19 Jan 1810 in Gibson County, IN, son of Isaac Creek & Sarah Gorin.
Jefferson married Nancy McDaniel and had the following children:
John Wesley b. 1837; Isaac born 1838; Jane Anne b. 1841; Mary b. 1843; Fanny b. 1845; Robert b. 1847; Sarah/Mary Ellen b. 1850; Emily b. 04 Apr 1852; Mary Etta b. 13 Sep 1855; Rachel Lavina b. 15 Sep 185_
I think you will find the Jefferson Creek family in Wayne County, IL before 1860.
Also I have Isaac Creek of Clay County, IL married on 04 Jan 1866 to Matilda A Quertemous...is this his 2nd wife ? Married to a Walston 1st ?
I have a photo of Nancy McDaniel Creek and another of her sons, John, Isaac & Robert.
Have additional info on this line, although it is all research, this is not my Creek lineage.