As far as I can tell, the Depoys in Rockingham Co. around 1800 were children of Isaac Depoy b. 15 Dec 1728 Reading, Berks, Pennsylvania, d. 5 Mar 1809 Rockingham Co., Virginia, and his wife Anna Maria Hauer, c. 5 Sep 1734 Blankenloch, Karlsruhe, Baden, Germany, d. 7 Oct 1789 Rockingham Co., VA.
The Depoys were German-speaking--likely German Baptist Brethren (closely associated with the Mennonites.) The Brethren came from German-speaking parts of Switzerland and France as well as from Germany.I am pretty sure the Yeakley were part of this community in Berks/Lancaster Co.
Starting about 1775, large numbers of these Pennsylvania Germans (aka, Pennsylvania Dutch) moved south from Berks and Lancaster Counties, PA, into the Shenendoah Valley of Virginia and formed German-speaking enclaves. The Depoys were part of this exodus.
I think George Yeakley Jr. and his brother John Jacob Yeakley settled in Frederick County, VA.(George may have married Anna Maria Grau b. 1767 in Heidelberg, Berks, PA.) I believe John Jacob died in Frederick County, VA, about 1844.
There also was a Christian Yeakle or Yakle who married Susannah Rodeheifer, 27 Aug 1796 in Shenandoah County, Virginia.Christian was on the 1810 census in Rockingham Co.Susannah was a widow on the 1830 census.I am not sure where Christian came from.
Several of the Depoy sons moved to Ross Co., Ohio, early. I think Anna's brother Michael Yeakley, may have moved to Ross Co. with them.
Here are the Depoys on the 1810 census in Rockingham Co. I think the five are brothers, all sons of Isaac Sr.
1810 Census Rockingham Co., Virginia
Depoy John 42010//10111[4m under 10, 2m 10-15, 1m 26-44, 1f under 10, 1f 16-25, 1f 26-44, 1f over 45]
Depoy Christopher 00001//0003 [1m over 45, 3f 26-45]
Depoy Conrad 11101//1211 [1m under 10, 1m 10-15, 1m 16-25, 1m over 45, 1f under 10, 2f 20-15, 1f 16-26, 1f over 45]]
Depoy Jacob 02010//01 0 1 [2m 10-15, 1m 26-44, 1f 10-16, 1f 26-44]
Depoy Isaac 30011//1 0 0 1 [3m under 10, 1m 26-44, 1m over 45, 1f under 10, 1f 26-44]
Isaac Jr. was not on subsequent Rockingham censuses.I believe he died about 1816, but he may have moved west with other members of the Depoy family. If I were looking, I would look at Ross Co., Ohio.
I do not have more information about Isaac, but I do have more information about other Depoys if you are interested.
P.S.The Yeakleys aren't my family, so I don't have a position on the issue, but there seems to be great disagreement about who George Sr. married.Some say Anna Deppen and others say Anna Laucks. I have seen some pretty testy exchanges on the issue.