I had an Uncle Frank DeSantis. His real name was Francisco. He was born about 1910 and immigated to New York from Italy in 1913. He had a brother Moe (Modesto), and Sisters - Val (Valentina), Connie (Concetta),Genny (Giovanna). They are probably all deceased now. Frank's wife was my Aunt Fanny, which I am sure was not her real name. My father "Moe" was 52 when I was born in 1954. So, my cousins were a lot older, and I don't remember any of their names. Does this sound like your relative?