I've been searching for these folks for over 10 years and still have very little on them.
James Mathew Durham was born about 1810 somewhere in TN. He m. Cynthia Lusk- possible daughter of Josiah Lusk. James is found in the 1840 Dekalb county, Alabama census but I can't find him anywhere after that. Cynthia and the family stays in Dekalb and she continues to have children who are named Durham. I have a list of all their descendants but I still can't find a marriage record although some of their daughters gave James as their father in an article published after they were grown. Cynthia did not declare herself a widow until 1880 and she died in 1887.