Sharon, I'm pretty sure that Isaac b: Sep 1839 and Lisle (also spelled Loyal or Liel) are cousins.My records show that Isaac married a Susan Jane b: Jul 1839, but I didn't have a last name for her.Lisle and Isaac shared the same grandfather John Edmiston, Sr.Lisle's father was John Edmiston, Jr. and Isaac's father was Philip H. Edmiston.
The Edmiston lineage is confusing in some areas, as there have been many things that took me a while to figure out and some that surprised me.
John Sr m: Ms. Eddington children are John Jr., Elizabeth, Nancy, Margaret, Rebecca, Mary, Philip H., Samuel & Isaac.
John Jr. m: Elizabeth Smith children are Lisle, Margaret, David S., John, William, Miles, Elias, Samuel, P. Rhodes & Mary.
Philip H. m: Letitia Stewart children are Mercy Mary, Angeline, Letitia, Isaac & Margaret.
I haven't been able to find that much info on the rest of their siblings, although I'm still looking.
Hopefully this information will either match your information or prove that somewhere along the way my info has gotten mixed up.Please let me know either way.