I, Tom Harding, is also a direct decendent of Sir James Esdaile from his son William Esdaile who married Elizabeth Jeffries. From this i am also a direct decendent of Percy Bysshe Shelley because Sir James Esdaile's grandson Edward Jeffries Esdaile 1813-1881 married Ianthe Eliza Shelley the only daughter of Percy Bysshe Shelley and his first wife Harriet Westbrooke before he married Mary Shelley.
I Have also got records of Sir James Esdaile's other children like James Esdaile 1780-1812 who married Sussannah Hadfeild, Sir Joseph Esdaile, Mary Esdaile and John Esdaile. These are the only children i have record of but i'm sure there are others.
I would love to hear from you. I also have a full family Tree of Sir James and hopefully i can send it to you or any one that is intrested. My e-mail address is firstname.lastname@example.org you can ask me anything you want from the Shelley or Esdaile family.