Generally, the earliest known Fiskes in America are Samuel, Nathan, David, John, William and possibly a few others. I believe they are all considered to be the descendants of Robert Fiske and Sibilla Go(u)ld of Laxfield. How they are related exactly has been debated for centuries as there are several sources that propose alternate relationships for some of these Fiskes. They are generally believed to have arrived between 1635 and 1642. The towns they appear in first are Ipswich, Wenham, Watertown and Salem... all in Massachusetts. That is, if I recall correctly. My ancestor was David Fiske of Watertown, who first appeared as a Freeman there, in 1637.
I hope this helped and if anyone has anything to add or refute please feel free.