Re: Susannah, b. ca. 1706 VA; m. John Thompson; was she a 2nd wife?
According to the Christ Church records, available online at
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Full text of "The parish register of Christ Church, Middlesex County, Va., from 1653 to 1812"
a Catherine "Tompson" died in Middlesex County "March ye 31. & was buried April ye 3. 1726".
I believe this was Catherine (Twyman) Thompson, and that John then married Susannah George on January 9, 1727 or 1728.