Hi Joan--You're not alone in researching the Gufford/McGufford family!
I too descend from this family. I descend from a Miss McGufford who married Hezekiah Bonham Sr. (Actually I descend from the Guffords a couple of times over--a first-cousin marriage way back when!!)
My line from Hezekiah Bonham Sr. goes thru his son Hezekiah Jr, then to Jr's daughter Ann (Nancy) Bonham who married Neill Henry of New Hanover County. (The Henry family came with a group of families from the Isle of Arran in Scotland just prior to the Revolution.)
Neill and Ann Bonham Henry were the parents of my great-great grandfather, Washington B Henry (in what is now Pender Co NC--around the town of Atkinson). Wash Henry served in the Confederacy during the Civil War and soon afterwards married Sarah Elizabeth Vann of Sampson Co NC.
Wash and Sallie Vann Henry's daughter Lessie (Celestial Ann) was my great-grandmother. Lessie married Gus Byrd from Harnett Co NC and their daughter Eunice (born 2 December 1895) was my maternal grandmother.
Grandma Eunice Byrd married my grandpa George Winter Futch (of Burgaw, Pender Co, NC) around Christmas of 1925. They had two children: my mom, Christine (married Max Hamilton in 1946) and my aunt Carol, who married Ferman Burns of (I think??) Bladen Co NC (not far from Pender Co line tho!)
So I promise you're not alone in looking for those elusive Guffords!! I am thinking they probably came from Scotland originally but have no proof--the first one I know of is a Nathaniel McGufford. I did some research a few years back on some LDS microfiche and the only McGuffords I came up with (aside from our Nathaniel's direct line) was a little girl born in (as I recall) Edinburgh Scotland sometime in the 1700'?? I remember that her mother's maiden name was Maxwell--have no idea why I remember that detail!! But like I said, nothing to tie them into our line--but it does indicate that some McGuffords DID live in Scotland. McGufford appears to be a very rare name! I've looked for it in all kinds of surname books--esp. Scottish and Irish surnames--but no luck so far. The closest I can come (phonetically) is McGuffock, which is said to be an ancient Galloway (SW Scotland) surname. BUT I don't know if the two names are truly related or not.
Incidentally, my computer is on its last legs and I'm now hunting for a new one--meanwhile believe it or not, I cannot send or receive emails!!! So while my email address is correct, at the moment it just isn't working--tiresome thing!! I hope to have that new computer before long. Anyway---I would love to correspond with you and other McGufford descendants!!