I'm from this line too. Through his son Jacob. The Guise name came from Claude de Guise the 1st Duke of Guise of Lorraine and France. The town Guise, France is named after the family. His ancestor Rene de Guise taught Christopher Columbus to sail. Antonio Frazier in her book, Mary Queen of Scots, calls the Guise family one of the most fasinating in history. Mary's mother was the daughter of Claude de Guise.