The information you have on Lewis Guss and his family is essentially the same as what I have.Lewis was married twice in PA, and his second wife was Sally Frain.Sally was the oldest child of Peter Frain and Rebecca Bilger.I don't know who Lewis' first wife was.Lewis and Sally had 18 children, eight of whom were still living in about 1899.
Elizabeth Guss was the daughter of Samuel (Simon) Guss and Barbara Knerr.She married Samuel Kerlin (Carlen), son of Samuel Kerlin, Sr. (wife unknown).
William Guss was the son of Samuel (Simon) Guss and Barbara Knerr.His first wife was Mary Foltz and his second wife was Eliza Wike (Wyke).She was the daughter of George and Mary (Polly) Essig Wike.
The only thing I have on Nicholas Guss is 3 entries:
Montgomery Co. NY, Palatin Twp. 1820 census Luzerne Co. PA, Denison Twp. 1840 census Centre Co. PA, Harris Twp. 1850 census
These are listed as "others named Guss" because no relationship could be established.