Isaac Towell married Sarah McAdams.Sarah McAdams was the siter Mary Adair McAdams who married Rev. James Gwin(NO A) Isaac and Sarah's children were... Ambrose, Mary "Polly", Samuel, Nancy, Margaret, Henry, Catharin "Caty, Matilda, Isaac, Sarah "Sally", William Miligam.
Nancy (#4) married David R. Gwin 16 Aug 1819 in Sumner Co TN.David R. Gwin was the son of Alexander Gwin.
Alexander Gwin was the older brother of Rev. James Gwin, whos wife was Mary Adair McAdams and the sister of Sarah McAdams Towell.Think that this works out to be 1st cousins twice?