David, Thank you for your quick response. I appologize for my slow one!
In answer to your question - My relative John (or James) Henderson was from Knox County, Ohio. His parents were Samuel Henderson (from Ireland) and Margaret B. Hurford. At this time I don't have any knowledge of all the children you mention. To the best of my knowledge John and Jessie had Anna and Eleanor and two others that didn't live past infancy or childhood.
I would be interested to learn whether there is an error in my information and if there is a connection to your Hendersons in Jefferson County.