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I have a Henry HUGHS/HUGHES b. c. 1780 who lived in Centre Co. Pa (Bellefonte, Pa) and is listed thru the 1840 Census there.
His wife is Martha Jane b. Pa and some of the known children:
Isabellab. 1822 - m. William MALLERY/MALLORY
John Davis Hughs/Hughes b. 1824/25 -my line in Altoona, Pa
Possibly there is a James and Thomas Hughes that were in the same area and the right age to be his children also.