Do you have any other information about this family? My GGG grandmother Nancy Hufford originally came from Bucks County. All the other Huffords seem to be around Maryland or other areas of PA.
It sounds like my Nancy might have been sister to John. Especially if John's mother's name was Nancy. However, my Nancy does not have a death certificate. She married Henrich Schmidt and moved to Tompkins County, NY, so was never included in the family history. I'd like to find more information to fit her into this family somewhere. I've been wondering if perhaps the Henry Hufford buried at Poplar Valley, Monroe County, PA might be a brother too.
Have you found any wills or land documents for these folks?