As far as birthplace of James Humes, that seems to be commonly credited as Castle Hume, Fermanaugh, Ireland around 1757. I have Elizabeth Hamilton as born in 1760 in Lancaster and died in Pike Co. OH in 1827.
James & Mary Hamilton were members of LEACOCK PRESBYTERIAN CHURCH, LANCASTER CO, PA. Per notes I have Mary is buried there.
per Egles Notes & Queries, 3d Series, Vol 3, pg 8
James was prominent in civic affairs - overseer of the poor in 1773 & 1776, appointed constable 1779, supervisor of roads 1781.
My uncle, James C. Humes, wrote a book some years ago on the Humes family and he noted that James Hamilton was a Sherriff, which is probably a reference to Egles's citation as Constable.
Hamilton gave land west of Lancaster to daughter Elizabeth and husband James Humes that he received as a grant as a Revolutionary War officer. Elizabeth and James moved there in 1803. Their oldest children, Mary (who was married) and Hamilton stayed behind in Lancaster County. Younger 5 children moved with them.
James and Elizabeth traveled across Alleghenies to a spot near Dunkard's Creek in the vicinity of Blacksville, Washington County PA.
My uncle doesn't cite sources. He recently mailed me some lists of sources used in his book that I need to match up.
Take a careful look at the Michael Robison info and will here if you are looking to connect up the Ohio Robison line to early PA lines:
Here's another interesting possible lead on the Robison family fromhttp://www.rootsweb.com/~usgenweb/pa/pafiles.htmhttp://www.rootsweb.com/~usgenweb/pa/pafiles.htm
LAWS OF PENNSYLVANIA GENEALOGICAL DATA
Source: The Statues at Large of Pennsylvania, Harrisburg PA, 1911
"58. An act to incorporate the Phillipsburg and Juniata Railroad company.
That ROBERT E. GRIFFITH and JONATHAN M. WRIGHT of the city of Philadephia,
HARDMAN PHILLIPS, THOMAS BURNSIDE and WILLIAM BAGSHAW of Phillipsburg, Centre county, and ROBERT ALLISON and WILLIAM ROBISON of Huntingdon county, are hereby appointed commissioners to survey, lay down, mark and fix a double or Aug 16, 1820single railroad, beginning at the Pa. canal, near the mouth of the Little Juniata, below Alexandria in Huntingdon county, thence to the Little Juniata and Little Bald Eagle creeks and through Emigh's gap, to the coal mines in the neighborhood of Phillipsburg in Centre county.16 Mar 1830."
I mentioned my Lycoming County Humes line's involvement in a Bald Eagle Branch RR line about 30 years later in another post. There is also a reference to a EDWARD W. ROBISON and aPine Creek RR in the same file and same era and that runs near Jersey Shore PA. So maybe this can help you connect your Anna Humes to the Bellefonte or Jersey Shore PA Humes families that had railroad connections in the same area.
Also in the same file is:
80. An act to enable MARY HAMILTON, widow of JAMES HAMILTON, late ofCumberland county deceased, ALEXANDER HAMILTON, a son of said deceased, whoas of full age, and MARY HAMILTON and JAMES GIVEN, guardians of the minor
children of the said deceased, to sell certain real estate.
Minor Children of James Hamilton of Middlesex Twp. Cumberland Co. PA. - JAMESHAMILTON JR., WILLIAM ELLIOT HAMILTON, and GEORGE PORTER HAMILTON. Widow,eldest son, and guardian are empowered to sell in private or public twotracts of land to pay debts. 1) land situated on the south east side ofSwatara Creek in Derry Twp., Dauphin County adjoining the town of Port Royaland land now of HENRY GROSS, MARTIN HARE and others containing 20 acres, 116perches on which is erected a stone merchant and grist mill, dwelling house,and other improvements, with dam, mill-works and water rights. 2) Tract ofmountain land situated on the Susquehanna River in Fairview Twp. York Countyadjoining lands of PHILIP CONCER, the heirs of GEORGE THOLLY, and the heirsof JACOB KERR dec. containing 20 1/2 acres.
Also the right, title and interest of said minor children to the followingtract of land situated on Iron Run in Londonderry Twp. Dauphin Countyadjoining lands now of CHRISTIAN HOSTETTER,of the heirs of HENRY B. GRUBB,dec., JACOB SINGER, JOHN SINGER, JACOB HERSHY and others containing 63 acresand 54 perches, on which are erected a stone grist mill, saw mill, hemp mill,plaster mill and distillery, stone dwelling house, stabling and otherimprovements. This land Mary Hamilton and guardian James Given purchased forchildren in trust for the purpose of securing a debt due from HENRY HAWK tothe estateof the deceased. 1 Apr 1830
That appears to be related to out Hamilton line via the Porter reference. I suspect this is related to the Alexander Hamilton the library in Waynesburg, PA was founded by and named after. One person told me a marriage certificate of a James Hamilton is framed on the walls there.
I also found the following Adams couty death notices of possible interest:
Aug 13, 1828 - On 4th, Isaac Robison, Mountpleasant, 84
Jan 6, 1813 - On (Dec) 23rd, Mrs. Sarah Robison, 69, consort of Isaac Robison of Mountpleasant twp.
Aug 4, 1819 - On 18th, Dr. James Hamilton, at Conrad Brown's Tavern in Franklin county
Apr 19, 1820 - On 10th, Col. William Hamilton, 49, Editor of Lancaster Journal
Aug 16, 1820 - Thursday last, Andrew M'Ilvain, 69, Hamilton (the Hamilton reference is a location but this is a surname married to Hamilton family in our tree)
Oct 1, 1823 - On 22nd at Campbells-town, Franklin county, William Hamilton, Cumberland twp.
"History of Franklin and Pickaway Counties, Ohio"
"Isaac Robison was a native of Pennsylvania, but was raised in Pike County,Ohio, where he married and had three children, Margaret, Jane, and Elizabeth. In 1822 he moved to Scioto where Sarah, James, John, Ann, David, Samuel, William, Joseph, Matilda, Caroline, Martha, and Almira were born -- In all fifteen. Thirteen are now living, five in Scioto, and all on farms: Mrs. Sarah Hall, Mrs. Matilda Hott, Mrs. Almira Hott, and Mrs. Ann Hoover. Michael Robison, the father of Isaac Robison, came with his family to Pike County, in 1819. In 1822 he moved to Picaway County, and bought two hundred and fifty acres of land, which he gave to his children, of whom he had six. He died in 1851, aged eighty years. The Robison?s settled in the south part of the township, and their settlement is known as Robtown." Conclusion Michael Robison born PA 1771 (per Bio above, 1775 per census) 1.  Isaac b.1796-1797 in PA (out of home and listed in 1820 census)..."
That is from http://www.rootsweb.com/~ohpickaw/98-99/query033.htmhttp://www.rootsweb.com/~ohpickaw/98-99/query033.htm,
which also has much more info on Robison lines in OH.
I'd look to prove a connection between the 84 year old Issac and this Michael apparently listed as father of your Isaac. There is also an Isaac listed in taxables prior to 1775 in Northumberland County, referenced only by name briefly in Bell's History of Northumberland County, PA - THE COLONIAL
PERIOD (Concluded) - Part III, with some Hamiltons also listed as early settlers there.