My information is slightly different. I have that Isaiah's first wife, Sarah Adams, was the mother of Samuel, Francis Marion, Derinda, Nancy and Reverdy J. After his first wife died, Isaiah married Eliza (who appears with him in the 1860 census). Isaiah's second wife, Eliza, was apparently the mother of Charles C., Seth G. and Kate. There may have been other children, but these are the only ones I have listed.
Another Charles (b 1859), was the son of Walter (b 1832), grandson of Ruby and Josiah (b 1807), and great grandson of Anna and Joab (b ca 1780).