My Great Grandfather was named George Nolan Lacewell. As far as I know he was born around the Dalton, GA area. He was a Cherokee descendant who attended medical school in Atlanta. The 1851 would be about right as my Grandmother was his last child and she was born in 1899 near Dallas, TX. His wife was Lida Kirk.
I do no know of any of our relatives being from Arkansas or Missouri but who knows.