Not a lot to work with, but here are some facts I found on the Internet.
The 1860 census shows Joanna F Debord as 18 in Smythe Co, VA.Her parents are: John 51 and Mary L 36. Based on your note, she married at 19 to John Louthan.
I did not find a James and Lucy Louthan in the census data.
These are the James Louthans in the area: John K 42 and Lucy 3 41 in 1870 in Clarke Co, VA James L (1840) and Barbara in Tazewell Co, VA James W (1851) and Thurs in Smythe Co, VA James T (1838) and Barbary in Tazewell Co, VA James A (1844) in Frederick Co, VA James (1839) in Frederick Co, VA James Carter (1859)in Berryville, VA James Thomas (1827) x Emeline[Clarke Co, VA] James Henderson (1796) x Mary[Frederick Co, VA] James Franklin (1828) x Harriet [Frederick Co, VA] Jmaes Hervey (1823) x Mary[Wythe Co, VA]
I note that the last fellow moved west to Iowa to Coon Rapids, Davis Co, IA.
I am familiar with most of these men, but none seems to fit the James x Lucy Louthan that you asked about.
Do you have any dates for year of birth, or year of marriage?
My extensive Louthan collection does not have the James x Lucy combination, so I need something to work with.