You might want to view www.myNorthfield.org to get an idea of the history of Northfield.Here is the beginning of that information:
"Prior to the first settlement of Northfield in 1670, the territory was occupied by a tribe of native Americans known as the Squakheags. A site west of the Connecticut River north of present day Route 10 was also a camp for King Philip in the Spring of 1676.
"The first group of white settlers, from Northampton, purchased a 10,500 acre tract from the Squakheags in 1671. An additional 3,000 acres on the west side of the Connecticut River was bought in 1673. It was at this time that the first settlement began. However, two years later the natives became hostile, and in September of 1675 the area was ravaged. Capt. Richard Beers of Hadley led the fight to save the village, but they were unsuccessful and he died in the skirmish. The settlement was abandoned."
It is very unlikely that your ancestress was born in Northfield as early as 1625.