I believe these Mackeys may be descended from the family of John Mackey, (Scots-Irish immigrant) of Augusta Co., VA, who had sons, Thomas, William, Solomon, and others. They are associated with my Duke family, in Lancaster, SC (Robert Duke, b 1784-5, and son Jesse Duke, b. 1770). They also are associated with the family of Joseph Crenshaw, son Micajah Crenshaw, and Benjamin Cook, who more or less migrated with Robt. Duke's family, from Lunenburg Co., VA, to Camden/Lancaster Co., SC. You can find the early Mackey family in Lyman Chalkley's "Chronicles of the Scotch-Irish Settlement in Augusta Co., VA, (RootsWeb-Ancestry hosted) Lunenburg Co., VA records, and Lancaster Co., SC Deeds and Wills, as well as the SC Archives online datbase search site. My Jesse Duke also deeded to Thomas Mackey in 1804; I have the deed, from my Duke family documents. Otis Fuller.