You will find a John Madison married to Isabel Minor (Todd?) in Virginia.This John is the great grandfather of Pres. James Madison.John and Isabel had the following children: Mary,Eleanor,Capt. John III,Ambrose;Henry,James,Roger,and Thomas.Ambrose is the grandfather of Pres. James Madison.
I have been looking into the descendants of Roger Madison that made it into Tennessee in the early 1800s from Virginia.There are at least two Samuel Madisons in that line, but no apparent connection to Kentucky.I have some information if you are interested.